The Royal United Hospital in Bath has ambitious plans for a £110m transformation over the next five years.
Old buildings will be demolished and replaced by new facilities including a Cancer Centre, pharmacy and integrated therapies unit.
RUH chief executive James Scott said: “The Trust is on the cusp of one of the most exciting periods of development and improvement in its history.
“We’ve had a fantastic year of delivering great quality care, as highlighted by our good Care Quality Commission report earlier this year and our commitment to improving safety was confirmed by our selection as one of 12 trusts chosen to lead the national Sign up to Safety campaign.
“We now have an exciting five-year plan firmly in place to help us build upon our reputation for providing the half a million people we serve with highest quality care.
“Transforming the site means we can transform the services we provide our patients and our newly-approved estate strategy will enable us to do just that – sweeping away poor quality buildings and providing a hospital estate that we can all be proud of.
"We are now poised to take the first step in what will be a very exciting journey. These plans will ensure we are in the best position to deliver excellent care now and in the future.”
*The RUH has restarted its bid to become a Foundation Trust. The regulator, Monitor, will begin its assessment of the RUH this month.